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PMID: 30741689

The P38 Mitogen-Activated Protein Kinase (MAPK) Pathway in Rheumatoid Arthritis

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Thus, due to the nature of the original diagnostic criteria for GHD, and the reticence to consider aging a disease per se, even though disease risk, incidence and severity can be attributed at least in part to declining activity of the GH neuroendcrine axis, the criteria for determining if secretagogue therapy is indicated as an intervention in aging, are less stringent than those promulgated by Endocrine Society guidelines

These potential mechanisms remain hypothetical and require further research to establish their clinical relevance